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KMID : 1144820220280020137
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대한의생명과학회지
2022 Volume.28 No. 2 p.137 ~ p.144
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Analgesic Effect of Poria cocos Extract on a Rat Model of Adjuvant-induced Arthritis
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Lee Gil-Hyun
Yoon Hae-Gyung
Choi Go-Eun
Hyun Kyung-Yae
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Abstract
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Poria cocos is a natural substance known to have anticancer, antioxidant and anti-inflammatory effects. The aim of this study is to investigate the analgesic effects of Poria cocos extract (PCE). We evaluated the analgesic effects of PCE using adjuvant induced arthritis rat model. Male SD rats were administered intra-orally with PCE according to prescribed dosage, during 6 days. After 6 days later, serum TNF-α, IL-1β, and IL-6 levels were measured by ELISA. In our experiment, administration of PCE decreased TNF-α, IL-1β, IL-6 and PGE2 level in serum. Furthermore, it was confirmed that allodynia was relieved in evaluation of pain behavior. It was confirmed that administration of PCE reduces nociceptive pain by reducing nociceptive stimuli by acting as an anti-inflammatory drug.
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KEYWORD
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Poria cocos, Adjuvant, Pain, Nociceptive pain, TNF-α, IL-1β, IL-6
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